Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis
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Ion-signaling and transduction networks are central to fungal development and virulence because they regulate gene expression, filamentation, host association, and invasion, pathogen stress response and survival. Dysregulation of ion homeostasis rapidly mediates cell death, forming the mechanistic basis by which a growing number of amphipathic but structurally unrelated compounds elicit antifun...
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ژورنال
عنوان ژورنال: ACS Infectious Diseases
سال: 2018
ISSN: 2373-8227,2373-8227
DOI: 10.1021/acsinfecdis.7b00215